Recent trends or the last 2 years sample size?
A-Rod being out doesn't really hurt the Yanks - both Chavez and Nunez were producing way more steadily than A-Rod has been since return. I'd worry about Jeter being close enough to 100% to matter and CC's mental health.
I think the value is more on the Yankees here - CC's last outing v's Oakland was actually pretty solid - Girardi just left him in an inning too long. Don't think he makes that mistake again. Lackey has been pitching very well of late, but the Yankees (despite losing) touched him up pretty well last time out.
Bottom line: CC's upside is way higher than Lackey's upside. Either you believe he will conquer his Red Sox demons or not. I say he does it tonight...
Prediction: Yankees 5, Red Sox 3