What are the mismatches between teams strengths and weaknesses that could lead to a blowout/close game?

The one that sticks out to me is the giants wr corps vs. eagles secondary. I love giants chances to get their offense back on track vs a struggling eagles secondary who has no signs of improving at all.

They've given up the 2ND most ypg through the air as well as second highest completion percentage. Opposing qbs put up a cumulative 107 rating vs them.... Granted the game vs Peyton inflated some of the numbers but that eli-cruz connection isnt too bad.

Anything else??