Came across what I think may be a significant piece of info. SF currently has the opportunity to set a franchise record for fewest points per game. Taken from ESPN's Mike Sando, read on:

They can set the record by holding their four remaining opponents to 14 points per game or fewer.

Top San Francisco 49ers Defenses
Rank Season PPG Allowed
1 2011 13.4
2 1976 13.6
3 1984 14.2
4 1992 14.8
5 1991 14.9
5 1990 14.9
The 49ers have allowed 161 points in 12 games, an average of 13.4 points per game. The 1976 team allowed 190 points in 14 games, or 13.6 per game. That means the current team must hold its remaining four opponents to beneath 57 combined points.

Interesting tidbit that may influence your bets, maybe not. Cheers