handicapping these games is much different. Motivation,Psychology,Coaching take a much bigger role and if you don't have a good handle on the personality of these teams be careful.
difficult how to cap how a slighted team reacts, some are out to prove something others give up.
look for young coaches that have turned a program around recently, they still have the fire and are looking to move up the ladder so every win is a chance to get seen by a bigger program eventually. They get their kids ready.
"I'm not racist BUT" Look for teams with multiple upper classmen White guys that play a lot. They typically have no illusion that they are going to play Professionally and know this is their last chance to play with hustle and heart.
Remember most games are held at higher seeds Home court. Sometimes with scheduling issues it can't be, so always check the location. Sometimes games are held during Spring break of that team. Take a 1 point off at least for home court advantage in that situation. Check the team webpage and twitter if possible.
look for smaller schools that will be on a ESPN or ESPN2. These kids know they'll be on a bigger stage and want to show out more as they don't typically play on the big ESPN channels
check that all players are still on team, this time of year coaches get fed up with goofballs that are always late, mouthing off, smoking weed ect. see alot of dismissals for breaking team rule type stuff.
post your angles here
good luck