Good
Bad
Doesn't Matter
I have really never gave this any thought. Not sure I have ever did this. On first thought, I would think it would be bad. Is it good or a bad thing to have a Defense in your lineup that is going against your starting QB? Or does it even matter? For example, this could be my starting QB and Defense in Week 7: C.Ponder Cardinals Defense Good. Bad. Doesn't Matter?
Just play the guys that will give you the highest score. However, if your going to watch the game, it might drive you crazy. I try to stay away from starting defenses that go up against my QB, but that is just because I watch the games.