This year is rather unique in fantasy football. RB's are very thin while the WR pool seems almost endless. If you can load up on Running Backs this year you could have a serious advantage in your league.
Wait until at least round 3, preferably round 4 to draft your first wide receiver. I've ran numerous mock drafts grabbing workhorse running backs to get you that consistent flow of points which will help win your league, while still having a very sold core of wide receivers. This works from any draft position.
Here is a list of WR's you can get in rounds 4-6 in a 10 team draft:
Victor Cruz
Hakeem Nicks
Julio Jones
Brandon Marshall
Jordy Nelson
Steve Smith
Dez Bryant
Marquis Colston
Brandon Lloyd
Miles Austin
Vincent Jackson
Dwayne Bowe
Percy Harvin
Looking in even later rounds you still have wide outs who are going to have a great season:
Antonio Brown
Eric Decker
DeSean Jackson
Demaryius Thomas
Jeremy Maclin
Stevie Johnson
My point is it's +EV to wait for your WR's. Why take Mike Wallace in round 2 when you can get Antonio Brown who will put up almost identical numbers in round 7? Same with Roddy White.... take Julio Jones a round later. Why take Greg Jennings when you can wait for Jordy Nelson?
Everyone else wasting picks on WR's in the early round will have absolute garbage at RB while their WR's will not be guaranteed to be worth their draft position.
I've run several 12 team mocks from position 10 for example that go like this:
Round 1: Option of MJD/Chris Johnson/Matt Forte
Round 2: Option of Demarco Murray/Lynch/Steven Jackson/AP/McFadden/Jamaal Charles
Round 3: Option of Fred Jackson/Frank Gore
Any one of those combinations would be an excellent 1-2-3 punch in a 12 team league this year. Then for WR you can have 2 of the following for example Jordy Nelson, Steve Smith, Antonio Brown, Eric Decker, Jeremy Maclin, while possibly using rounds 6 and 7 to grab a Phillip Rivers, Matt Ryan, Jason Witten... the possibilities are endless.
Drafting RB's 1-2-3 won me my league last year.. I destroyed everyone with my combo of Ray Rice-LeSean McCoy-Fred Jackson while still have sold WR's. Just be patient this year because the WR pool is deep.