South Florida -22 over East Carolina: The Bulls (41.5 ppg Scoring Offense, Tied #33) rolled in this game at last year in Greeneville, 61-31, and ECU (1-1 SU/ATS) is 6-18 ATS L24, having failed to cover games ATS consecutively over that span. With host USF (3-0 SU, 1-2 ATS) a profitable 8-4 ATS L12 as Home Favorites and the Pirates 2-9 ATS L11 as Road Dogs—they did upset NC in Week 3, 41-19—looking for the Bulls to win their 32nd game in their L36. Prediction: USF 45 ECU 17
Memphis -27½ over South Alabama: So strong at Home (5-1 ATS L6), Memphis (2-1 SU/ATS) does a better job than anyone in FBS in moving the ball upfield (+9.4 ypp, #1), and with a respectable Defense (18.0 ppg, #46) which is tied at #9 with a +2.0 Turnover Margin, the Jaguars (19.5 ppg, Tied #107) will be in the wrong place at the wrong time at Liberty Bowl Memorial Stadium on Saturday in the first meeting ever between the Jaguars and Tigers. Prediction: Memphis 63 South Alabama 16
#13 Virginia Tech -27.5 over Old Dominion: The Hokies (2-0 SU/ATS) won this game at Blacksburg last season, 38-0, and are a perfect 19-0 when leading at Half under HC Fuente. With VT (10.0 ppg Scoring Defense, #16) so stingy and ball-savvy (+3.0 TO, Tied #2), and the Monarchs 0-3 SU/ATS averaging just 15.0 ppg (#122), expecting a blowout in Greenville. Prediction: VT 46 ODU 10