The 49ers took their medicine last week in an embarrassing NFL betting performance against the Seahawks. Now San Fran looks to turn the tables against Drew Brees and the New Orleans Saints.
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Just eight days after getting smacked by the Seattle Seahawks, the San Francisco 49ers will look to level their record on the season in one of their biggest games of the year, as the New Orleans Saints come to town. This Monday Night Football betting affair might be a potential playoff preview, as both of these teams are expected to win their respective divisions.

Alex SmithBad Medicine Given to Niners in Week 1

Boy, to be a fly on the wall in the San Fran practices this week. Head coach Mike Singletary has always had a way with words, and he has also never had a fear about challenging his players, both in private and in the media.

Last week's 31-6 loss at Qwest Field caused Singletary to come out and make a bit of a shocking statement to NFL odds makers about his team's performance. He told the Seattle Times, "Tell [Seahawks head coach] Pete Carroll thank you very much for kicking our tails. It was good medicine, and we're going to take it."

And why not? San Francisco was absolutely taken behind the shed in every facet of the game after dominating in the first quarter and a half of play.

The Niners had some major red zone problems, going 0-for-3 in terms of scoring TDs inside the 20 and only having a pair of 23 yard field goals to show for their entire day's worth of work.

Quarterback Alex Smith was atrocious at times, especially in the second half. He went just 26-of-45 for 225 yards with no TDs and two picks, one of which was returned for a TD. Save TE Vernon Davis, who had eight catches for 73 yards, no one else on the offense had a game that was even worth mentioning.

Running back Frank Gore needs to do better for the Niners to win this game, as rushing for 38 yards on 17 carries certainly won't cut it yet again for the hosts.

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Defending Champs Need to Be a Monday Night Delight

There was just something about the way that the Saints played last week that left a level of uneasiness about the season for the Bayou faithful. On the night that they raised their first Super Bowl banner in the Louisiana Superdome, the hosts came up with a questionable 14-9 win over the Minnesota Vikings. They did come up with a cover against the closing  NFL spread of 4½, but many were sitting on tickets with New Orleans -5½ on it that ended up being losers.

Quarterback Drew Brees was thought to be able to throw for well over 4,000 yards yet again this year. However, after going 27-of-36 for 237 yards and a TD against an above average, but not spectacular defense, those thoughts of 4,000+ yards might be premature.

The running game needs to be more consistent as well. Watching RB Pierre Thomas rumble for 71 yards on 19 carries against a solid defense was nice, but RB Reggie Bush needs more than two carries to be a difference maker in any game this year.

Wide receiver Marques Colston was the only man that had more than 40 receiving yards on the day in black and gold.

Niners Need to Knock Off Nightmarish History with Saints

New Orleans is a whopping 10-2 against the spread in its last 12 meetings against the 49ers. The Niners haven't won a game in this series SU since 2002, something that Singletary is certainly telling his team about in practice this week.

New Orleans is 7-1-1 ATS in its last nine games played on grass, but San Fran is 16-5 ATS in its last 21 showings on Monday Night Football.

The last time these two teams met was in 2008, and the Saints walked away with a 31-17 victory. The year before, they met in San Fran, with the visitors taking away a 31-10 win. New Orleans has scored at least 30 points in four straight meetings.

It should be no surprise that the 49ers are six-point underdogs tonight. If you're looking to get into this line or the 'total' of 44, be sure to sign up for an account at BoDog Sportsbook!

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