1) By "huge", I mean the underdog ML is at least +200.
2) These are not listed as plays but a way of eliciting a discourse that could be potentially beneficial to the board in deciding either which dogs to back or which favorites to avoid.
Here are my suggestions based on either the vulnerability of the favorite or the unique strengths of the underdog or both:
ATP
Nishioka +255 vs Anderson
Schwartzman +725 vs Del Potro
Dzhumhur +645 vs Tomic
WTA
Townsend +290 vs Wozniacki
Crawford +355 vs Bencic
Zheng +250 vs Puig
Allertova +215 vs Ivanovic
Parmentier +305 vs Garcia
Hibino +225 vs Mladenovic