florida state -4. This is a no brainer for me, louisville has had a very weak schedule. They lost to a weaker opposition in Virginia, they also lost to Clemson. The same Clemson that lost to WINSTON-LESS FSU. Louisville's defensive number is a little overrated because of the strength of schedule. They havent really faced a tough opposition asides from clemson.
Florida state has a better passing offense and almost in the same category in the rushing offense. Louisville will not be able to keep up with FSU. I think FSU has a point to prove to everybody that they are still the reigning National champions. my pick is FSU -4