Bet wisely, as the Michigan State Spartan's College Football team has one of the best defenses in the country & they’ll face an absolute offensive juggernaut in the Oregon Ducks Saturday.

A Lot on the Line
Michigan State has dropped four of five non-conference road games since 2008, which is important to consider when making your Week 2 College Football picks, as it continues its march in hopes of landing one of four spots in the upcoming football playoff.

The Spartans have compiled a 26-10 record against non-conference opponents during the Mark Dantonio era, but 20 of those victories have come at Spartan Stadium in East Lansing. 

Over the last two-plus seasons, the program is 5-2 SU and 7-0 ATS as underdogs, with the 'under' going 4-3 in that situation.

 

Home-field Advantage
The host has won all four prior meetings in this Big 12 versus Pac-12 matchup, while Oregon has won 22 of its 31 games against ranked opponents since 2002, which can’t be ignored when looking over the college football odds page Saturday afternoon.

The Ducks opened up their 2014 campaign with a 62-13 victory over South Dakota as 52-point home favorites last Saturday—winning the statistical battle by 303 yards.

It’s important to point out that this squad has gone 12-5 SU and 7-9-1 ATS as home favorites of 10.5 to 14 points in its last 17 opportunities.

 

Stop Unit
The Spartans have led the Big Ten in total and rushing defense the past three seasons, while they held all 14 of their opponents in 2013 under their season average in points and total offense.

Michigan State is going to have a hard time containing Oregon’s high-octane attack with just five starters returning from a year ago, especially with the departures of linebackers Denicos Allen and Max Bullough.

 

Mariota
Marcus Mariota is tied with Darron Thomas for the Ducks all-time record of 66 touchdown passes—one of many reasons why the junior is one of the betting favorites to capture the 2014 Heisman Trophy.

He has thrown at least one touchdown in 27 straight games, while he also benefits from handing the ball off to running backs Byron Marshall and Thomas Tyner, who combined for 154 rushing yards on 19 carries in the season opener.

 

Prediction
I’m going to recommend that readers play the total as one of their Week 2 college football predictions, as the Spartans will struggle to contain the Ducks due to their team speed offensively.

Michigan State allowed an average of 372 yards in games against Indiana, Nebraska and Ohio State last year—three teams that are known to have a bit of speed in the Big Ten—but nothing like that of Oregon.

Free College Football Pick: Bet over the total at YouWager